diff --git a/homeassistant/components/nightscout/__init__.py b/homeassistant/components/nightscout/__init__.py
index 798fcf1ec9d..9e01a2712ab 100644
--- a/homeassistant/components/nightscout/__init__.py
+++ b/homeassistant/components/nightscout/__init__.py
@@ -16,8 +16,10 @@ from .const import DOMAIN
 PLATFORMS = [Platform.SENSOR]
 _API_TIMEOUT = SLOW_UPDATE_WARNING - 1
 
+type NightscoutConfigEntry = ConfigEntry[NightscoutAPI]
 
-async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
+
+async def async_setup_entry(hass: HomeAssistant, entry: NightscoutConfigEntry) -> bool:
     """Set up Nightscout from a config entry."""
     server_url = entry.data[CONF_URL]
     api_key = entry.data.get(CONF_API_KEY)
@@ -28,8 +30,7 @@ async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
     except (ClientError, TimeoutError, OSError) as error:
         raise ConfigEntryNotReady from error
 
-    hass.data.setdefault(DOMAIN, {})
-    hass.data[DOMAIN][entry.entry_id] = api
+    entry.runtime_data = api
 
     device_registry = dr.async_get(hass)
     device_registry.async_get_or_create(
@@ -46,10 +47,6 @@ async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
     return True
 
 
-async def async_unload_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
+async def async_unload_entry(hass: HomeAssistant, entry: NightscoutConfigEntry) -> bool:
     """Unload a config entry."""
-    unload_ok = await hass.config_entries.async_unload_platforms(entry, PLATFORMS)
-    if unload_ok:
-        hass.data[DOMAIN].pop(entry.entry_id)
-
-    return unload_ok
+    return await hass.config_entries.async_unload_platforms(entry, PLATFORMS)
diff --git a/homeassistant/components/nightscout/sensor.py b/homeassistant/components/nightscout/sensor.py
index de1dadf1143..126a568a1d1 100644
--- a/homeassistant/components/nightscout/sensor.py
+++ b/homeassistant/components/nightscout/sensor.py
@@ -10,12 +10,12 @@ from aiohttp import ClientError
 from py_nightscout import Api as NightscoutAPI
 
 from homeassistant.components.sensor import SensorDeviceClass, SensorEntity
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import ATTR_DATE, UnitOfBloodGlucoseConcentration
 from homeassistant.core import HomeAssistant
 from homeassistant.helpers.entity_platform import AddConfigEntryEntitiesCallback
 
-from .const import ATTR_DELTA, ATTR_DEVICE, ATTR_DIRECTION, DOMAIN
+from . import NightscoutConfigEntry
+from .const import ATTR_DELTA, ATTR_DEVICE, ATTR_DIRECTION
 
 SCAN_INTERVAL = timedelta(minutes=1)
 
@@ -26,11 +26,11 @@ DEFAULT_NAME = "Blood Glucose"
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: NightscoutConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the Glucose Sensor."""
-    api = hass.data[DOMAIN][entry.entry_id]
+    api = entry.runtime_data
     async_add_entities([NightscoutSensor(api, "Blood Sugar", entry.unique_id)], True)