diff --git a/extensions/typescript-language-features/src/commands/index.ts b/extensions/typescript-language-features/src/commands/index.ts
index 919b1b749c5..7130f201975 100644
--- a/extensions/typescript-language-features/src/commands/index.ts
+++ b/extensions/typescript-language-features/src/commands/index.ts
@@ -3,14 +3,15 @@
  *  Licensed under the MIT License. See License.txt in the project root for license information.
  *--------------------------------------------------------------------------------------------*/
 
+import { PluginManager } from '../tsServer/plugins';
 import TypeScriptServiceClientHost from '../typeScriptServiceClientHost';
 import { ActiveJsTsEditorTracker } from '../ui/activeJsTsEditorTracker';
 import { Lazy } from '../utils/lazy';
-import { PluginManager } from '../tsServer/plugins';
 import { CommandManager } from './commandManager';
 import { ConfigurePluginCommand } from './configurePlugin';
 import { JavaScriptGoToProjectConfigCommand, TypeScriptGoToProjectConfigCommand } from './goToProjectConfiguration';
 import { LearnMoreAboutRefactoringsCommand } from './learnMoreAboutRefactorings';
+import { OpenJsDocLinkCommand } from './openJsDocLink';
 import { OpenTsServerLogCommand } from './openTsServerLog';
 import { ReloadJavaScriptProjectsCommand, ReloadTypeScriptProjectsCommand } from './reloadProject';
 import { RestartTsServerCommand } from './restartTsServer';
@@ -33,4 +34,5 @@ export function registerBaseCommands(
 	commandManager.register(new ConfigurePluginCommand(pluginManager));
 	commandManager.register(new LearnMoreAboutRefactoringsCommand());
 	commandManager.register(new TSServerRequestCommand(lazyClientHost));
+	commandManager.register(new OpenJsDocLinkCommand());
 }
diff --git a/extensions/typescript-language-features/src/commands/openJsDocLink.ts b/extensions/typescript-language-features/src/commands/openJsDocLink.ts
new file mode 100644
index 00000000000..10a480a4bd3
--- /dev/null
+++ b/extensions/typescript-language-features/src/commands/openJsDocLink.ts
@@ -0,0 +1,28 @@
+/*---------------------------------------------------------------------------------------------
+ *  Copyright (c) Microsoft Corporation. All rights reserved.
+ *  Licensed under the MIT License. See License.txt in the project root for license information.
+ *--------------------------------------------------------------------------------------------*/
+
+import * as vscode from 'vscode';
+import { Command } from './commandManager';
+
+export interface OpenJsDocLinkCommand_Args {
+	readonly file: vscode.Uri;
+	readonly position: vscode.Position;
+}
+
+/**
+ * Proxy command for opening links in jsdoc comments.
+ *
+ * This is needed to avoid incorrectly rewriting uris.
+ */
+export class OpenJsDocLinkCommand implements Command {
+	public static readonly id = '_typescript.openJsDocLink';
+	public readonly id = OpenJsDocLinkCommand.id;
+
+	public async execute(args: OpenJsDocLinkCommand_Args): Promise<void> {
+		await vscode.commands.executeCommand('vscode.open', vscode.Uri.from(args.file), <vscode.TextDocumentShowOptions>{
+			selection: new vscode.Range(args.position, args.position),
+		});
+	}
+}
diff --git a/extensions/typescript-language-features/src/languageFeatures/util/textRendering.ts b/extensions/typescript-language-features/src/languageFeatures/util/textRendering.ts
index f94eca76818..4eef8c1b963 100644
--- a/extensions/typescript-language-features/src/languageFeatures/util/textRendering.ts
+++ b/extensions/typescript-language-features/src/languageFeatures/util/textRendering.ts
@@ -4,7 +4,9 @@
  *--------------------------------------------------------------------------------------------*/
 
 import * as vscode from 'vscode';
+import { OpenJsDocLinkCommand, OpenJsDocLinkCommand_Args } from '../../commands/openJsDocLink';
 import type * as Proto from '../../tsServer/protocol/protocol';
+import * as typeConverters from '../../typeConverters';
 
 export interface IFilePathToResourceConverter {
 	/**
@@ -160,13 +162,15 @@ function convertLinkTags(
 			case 'link':
 				if (currentLink) {
 					if (currentLink.target) {
-						const link = filePathConverter.toResource(currentLink.target.file)
-							.with({
-								fragment: `L${currentLink.target.start.line},${currentLink.target.start.offset}`
-							});
+						const file = filePathConverter.toResource(currentLink.target.file);
+						const args: OpenJsDocLinkCommand_Args = {
+							file: { ...file.toJSON(), $mid: undefined }, // Prevent VS Code from trying to transform the uri,
+							position: typeConverters.Position.fromLocation(currentLink.target.start)
+						};
+						const command = `command:${OpenJsDocLinkCommand.id}?${encodeURIComponent(JSON.stringify([args]))}`;
 
 						const linkText = currentLink.text ? currentLink.text : escapeMarkdownSyntaxTokensForCode(currentLink.name ?? '');
-						out.push(`[${currentLink.linkcode ? '`' + linkText + '`' : linkText}](${link.toString()})`);
+						out.push(`[${currentLink.linkcode ? '`' + linkText + '`' : linkText}](${command})`);
 					} else {
 						const text = currentLink.text ?? currentLink.name;
 						if (text) {
@@ -232,6 +236,7 @@ export function documentationToMarkdown(
 	const out = new vscode.MarkdownString();
 	appendDocumentationAsMarkdown(out, documentation, tags, filePathConverter);
 	out.baseUri = baseUri;
+	out.isTrusted = { enabledCommands: [OpenJsDocLinkCommand.id] };
 	return out;
 }
 
@@ -251,5 +256,8 @@ export function appendDocumentationAsMarkdown(
 			out.appendMarkdown('\n\n' + tagsPreview);
 		}
 	}
+
+	out.isTrusted = { enabledCommands: [OpenJsDocLinkCommand.id] };
+
 	return out;
 }
diff --git a/extensions/typescript-language-features/src/test/unit/textRendering.test.ts b/extensions/typescript-language-features/src/test/unit/textRendering.test.ts
index cf6bdfb07ed..2354bb7f589 100644
--- a/extensions/typescript-language-features/src/test/unit/textRendering.test.ts
+++ b/extensions/typescript-language-features/src/test/unit/textRendering.test.ts
@@ -152,7 +152,7 @@ suite('typescript.previewer', () => {
 				{ "text": "}", "kind": "link" },
 				{ "text": " b", "kind": "text" }
 			], noopToResource),
-			'a [`dog`](file:///path/file.ts#L7%2C5) b');
+			'a [`dog`](command:_typescript.openJsDocLink?%5B%7B%22file%22%3A%7B%22path%22%3A%22%2Fpath%2Ffile.ts%22%2C%22scheme%22%3A%22file%22%7D%2C%22position%22%3A%7B%22line%22%3A6%2C%22character%22%3A4%7D%7D%5D) b');
 	});
 
 	test('Should render @linkcode text as code', async () => {
@@ -173,6 +173,6 @@ suite('typescript.previewer', () => {
 				{ "text": "}", "kind": "link" },
 				{ "text": " b", "kind": "text" }
 			], noopToResource),
-			'a [`husky`](file:///path/file.ts#L7%2C5) b');
+			'a [`husky`](command:_typescript.openJsDocLink?%5B%7B%22file%22%3A%7B%22path%22%3A%22%2Fpath%2Ffile.ts%22%2C%22scheme%22%3A%22file%22%7D%2C%22position%22%3A%7B%22line%22%3A6%2C%22character%22%3A4%7D%7D%5D) b');
 	});
 });
diff --git a/src/vs/base/common/htmlContent.ts b/src/vs/base/common/htmlContent.ts
index 107ee2c4feb..c3b79a8e2e0 100644
--- a/src/vs/base/common/htmlContent.ts
+++ b/src/vs/base/common/htmlContent.ts
@@ -118,7 +118,7 @@ export function isMarkdownString(thing: any): thing is IMarkdownString {
 		return true;
 	} else if (thing && typeof thing === 'object') {
 		return typeof (<IMarkdownString>thing).value === 'string'
-			&& (typeof (<IMarkdownString>thing).isTrusted === 'boolean' || (<IMarkdownString>thing).isTrusted === undefined)
+			&& (typeof (<IMarkdownString>thing).isTrusted === 'boolean' || typeof (<IMarkdownString>thing).isTrusted === 'object' || (<IMarkdownString>thing).isTrusted === undefined)
 			&& (typeof (<IMarkdownString>thing).supportThemeIcons === 'boolean' || (<IMarkdownString>thing).supportThemeIcons === undefined);
 	}
 	return false;